Inhibition of prostate cancer metastatic colonization by ?4.2 Mb of human chromosome 12
نویسندگان
چکیده
منابع مشابه
Suppression of tumorigenicity of human prostate cancer cells by introduction of human chromosome del(12)(q13).
The introduction of normal chromosomes into tumor cells by microcell fusion-mediated transfer is a powerful technique to identify putative tumor suppressor genes. We have used this approach to independently transfer human chromosomes 3 and 12 into a human prostate cancer cell line, DU 145. We showed that while the extra copy of chromosome 3 had no effect on the in vivo tumorigenicity of these c...
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Accelerated Ca entry may be one component of the pathway regulating the proliferative phenotype of some types of cancer. Thus, a pharmacological agent with the ability to retard Ca influx in susceptible cancers might inhibit proliferation of them by a cytostatic mechanism rather than by inducing cytotoxicity. We have developed a chemical synthetic scheme that has produced a small library of nov...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2003
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.11483